Tottenham players have historically been well represented in the Young Player of the Year award, having won five out out of the last six seasons: Dele in 2016-17 and 2015-16, Harry Kane in 2014-15, and Gareth Bale in 2012-13 and 2011-12.
The winners for both awards, voted for by PFA members, will be announced at a ceremony at London's Grosvenor House on 22 April.
Former Manchester City defender Joleon Lescott said: 'It is hard to choose but De Bruyne pips Salah because he has helped City win the league'.
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Salah has also scored 9 Champions League goal, and his impressive performance led to his side ousting Manchester City from the European elite championship at the quarterfinal stage.
United will have been disappointed not to get closer to runaway leaders City this term, though one constant for them has been the form of De Gea, who is the only goalkeeper among the nominees.
Operating primarily on City's left flank, the 22-year-old Sane has really come into his own this season.
Salah is now on track as he leads the top scorers list of the PL with 29 goals, with a wide gap between him and Harry Kane who has four goals.
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The abiding sense is of a club, once the envy of many in the Premier League, coming to the end of its cycle in the top flight. The turnaround was complete with 12 minutes left when Giroud reacted quickest to loose ball to volley into the bottom corner.
However, Salah has emerged as a real challenger to the Belgian after maintaining his outstanding form in the Premier League.
The final two contenders come from champions-elect Manchester City, with Sane and Silva in the reckoning.
The Belgium worldwide was the leading contender heading into the second half of the Premier League season but De Bruyne's form has dipped in recent weeks.
Chelsea's French midfielder N'Golo Kante was the last player to win the Player of the Year award in 2017.
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